Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit

Abstract: The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system. (end of abstract)

USPTO Applicaton #: #20050186627 - Class: 435006000 (USPTO)
Related Patent Categories: Chemistry: Molecular Biology And Microbiology, Measuring Or Testing Process Involving Enzymes Or Micro-organisms; Composition Or Test Strip Therefore; Processes Of Forming Such Composition Or Test Strip, Involving Nucleic Acid

Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit description/claims

The Patent Description & Claims data below is from USPTO Patent Application 20050186627, Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit.

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